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Shuting ZHANG, Bo WEI, Xin YU, Bing LIU, Zhuoying WU, Li GU
《环境科学与工程前沿(英文)》 2010年 第4卷 第4期 页码 459-465 doi: 10.1007/s11783-010-0249-3
关键词: bacterial DNA extraction biological activated carbon (BAC) biofilm water treatment pretreatment protocol
Modified pretreatment method for total microbial DNA extraction from contaminated river sediment
Yun FANG,Meiying XU,Xingjuan CHEN,Guoping SUN,Jun GUO,Weimin WU,Xueduan LIU
《环境科学与工程前沿(英文)》 2015年 第9卷 第3期 页码 444-452 doi: 10.1007/s11783-014-0679-4
关键词: river sediment DNA extraction contaminant pretreatment microbial community
Bacterial inactivation, DNA damage, and faster ATP degradation induced by ultraviolet disinfection
Chao Yang, Wenjun Sun, Xiuwei Ao
《环境科学与工程前沿(英文)》 2020年 第14卷 第1期 doi: 10.1007/s11783-019-1192-6
关键词: UV disinfection DNA damage qPCR ATP
结合基于滤纸的DNA提取技术和RPA-LFD检测技术对有毒植物钩吻进行快速鉴别
郑夏生, 安文丽, 姚晖, 徐江, 陈士林
《工程(英文)》 2021年 第7卷 第1期 页码 14-16 doi: 10.1016/j.eng.2020.02.012
Entity and relation extraction with rule-guided dictionary as domain knowledge
《工程管理前沿(英文)》 页码 610-622 doi: 10.1007/s42524-022-0226-0
关键词: entity extraction relation extraction prior knowledge domain rule
工程化DNA材料构建DNA活字系统实现可持续的数据存储 Article
巩子祎, 宋理富, 裴广胜, 董雨菲, 李炳志, 元英进
《工程(英文)》 2023年 第29卷 第10期 页码 130-136 doi: 10.1016/j.eng.2022.05.023
DNA分子作为一种具有潜力的数据存储绿色材料,具有密度高和保存期长的优势。然而,目前DNA数据存储的数据写入依赖于DNA从头合成,写入成本高昂,且产生有害物,限制了其实际应用。在本研究中,我们开发了一种DNA活字存储系统,该系统可以利用由细胞工厂预生产的DNA活字片段进行数据写入。在这个系统中,这些预先生成的DNA片段,在这里称为“DNA活字”,是可重复使用的基本数据单元。通过这些DNA活字的快速组装来实现数据写入,从而避免了昂贵且对环境有害的DNA化学合成过程。通过DNA活字片段的反复使用和生物组装,该系统在降低写入成本方面的潜力非常突出,为经济和可持续的DNA数据存储技术开辟了一条新颖路线。
关键词: 合成生物学 DNA信息存储 DNA活字存储系统 经济性DNA数据存储
Antibiotic resistome mostly relates to bacterial taxonomy along a suburban transmission chain
《环境科学与工程前沿(英文)》 2022年 第16卷 第3期 doi: 10.1007/s11783-021-1466-7
• The α-diversities of resistome were lower in manure and compost than in soils.
关键词: Antibiotic resistance genes Resistome Bacterial taxonomy Transmission chain
《环境科学与工程前沿(英文)》 2021年 第15卷 第3期 doi: 10.1007/s11783-020-1334-x
• Light haze had little effect on bacterial communities.
关键词: Bacterial community Persistent fog and haze Particle size
Huan GU, Dacheng REN
《化学科学与工程前沿(英文)》 2014年 第8卷 第1期 页码 20-33 doi: 10.1007/s11705-014-1412-3
关键词: surface engineering materials bacterial adhesion biofilm control review
The role of PARP1 in the DNA damage response and its application in tumor therapy
null
《医学前沿(英文)》 2012年 第6卷 第2期 页码 156-164 doi: 10.1007/s11684-012-0197-3
Single-strand break repair protein poly(ADP-ribose) polymerase 1 (PARP1) catalyzes the poly(ADP-ribosyl)ation of many key proteins in vivo and thus plays important roles in multiple DNA damage response pathways, rendering it a promising target in cancer therapy. The tumor-suppressor effects of PARP inhibitors have attracted significant interest for development of novel cancer therapies. However, recent evidence indicated that the underlying mechanism of PARP inhibitors in tumor therapy is more complex than previously expected. The present review will focus on recent progress on the role of PARP1 in the DNA damage response and PARP inhibitors in cancer therapy. The emerging resistance of BRCA-deficient tumors to PARP inhibitors is also briefly discussed from the perspective of DNA damage and repair. These recent research advances will inform the selection of patient populations who can benefit from the PARP inhibitor treatment and development of effective drug combination strategies.
关键词: PARP1 synthetic lethality PARP inhibitor DNA repair cancer NHEJ
Functional role of ATM in the cellular response to DNA damage
Ming LIU, Wenxiang HU
《化学科学与工程前沿(英文)》 2011年 第5卷 第2期 页码 179-187 doi: 10.1007/s11705-009-0268-4
关键词: ataxia-telangiectasia mutated (ATM) cell cycle checkpoint DNA damage signalling transduction
Generation and repair of AID-initiated DNA lesions in B lymphocytes
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 201-216 doi: 10.1007/s11684-014-0324-4
Activation-induced deaminase (AID) initiates the secondary antibody diversification process in B lymphocytes. In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination (CSR), both of which require AID. AID induces U:G mismatch lesions in DNA that are subsequently converted into point mutations or DNA double stranded breaks during SHM/CSR. In a physiological context, AID targets immunoglobulin (Ig) loci to mediate SHM/CSR. However, recent studies reveal genome-wide access of AID to numerous non-Ig loci. Thus, AID poses a threat to the genome of B cells if AID-initiated DNA lesions cannot be properly repaired. In this review, we focus on the molecular mechanisms that regulate the specificity of AID targeting and the repair pathways responsible for processing AID-initiated DNA lesions.
关键词: class switch recombination somatic hypermutation activation-induced deaminase DNA repair genomic instability
Molecular simulation of the interaction mechanism between CodY protein and DNA in
Linchen Yuan, Hao Wu, Yue Zhao, Xiaoyu Qin, Yanni Li
《化学科学与工程前沿(英文)》 2019年 第13卷 第1期 页码 133-139 doi: 10.1007/s11705-018-1737-4
null
《医学前沿(英文)》 2015年 第9卷 第3期 页码 261-274 doi: 10.1007/s11684-015-0406-y
Environmental pollution is one of the main causes of human cancer. Exposures to environmental carcinogens result in genetic and epigenetic alterations which induce cell transformation. Epigenetic changes caused by environmental pollution play important roles in the development and progression of environmental pollution-related cancers. Studies on DNA methylation are among the earliest and most conducted epigenetic research linked to cancer. In this review, the roles of DNA methylation in carcinogenesis and their significance in clinical medicine were summarized, and the effects of environmental pollutants, particularly air pollutants, on DNA methylation were introduced. Furthermore, prospective applications of DNA methylation to environmental pollution detection and cancer prevention were discussed.
关键词: environmental pollution DNA methylation cancer biomarker diagnosis therapy prevention
Effects of DNA damage on oocyte meiotic maturation and early embryonic development
Shen YIN,Junyu MA,Wei SHEN
《农业科学与工程前沿(英文)》 2014年 第1卷 第3期 页码 185-190 doi: 10.15302/J-FASE-2014035
标题 作者 时间 类型 操作
Development of pretreatment protocol for DNA extraction from biofilm attached to biologic activated carbon
Shuting ZHANG, Bo WEI, Xin YU, Bing LIU, Zhuoying WU, Li GU
期刊论文
Modified pretreatment method for total microbial DNA extraction from contaminated river sediment
Yun FANG,Meiying XU,Xingjuan CHEN,Guoping SUN,Jun GUO,Weimin WU,Xueduan LIU
期刊论文
Bacterial inactivation, DNA damage, and faster ATP degradation induced by ultraviolet disinfection
Chao Yang, Wenjun Sun, Xiuwei Ao
期刊论文
Characterization of bacterial communities during persistent fog and haze events in the Qingdao coastal
期刊论文
Materials and surface engineering to control bacterial adhesion and biofilm formation: A review of recent
Huan GU, Dacheng REN
期刊论文
Molecular simulation of the interaction mechanism between CodY protein and DNA in
Linchen Yuan, Hao Wu, Yue Zhao, Xiaoyu Qin, Yanni Li
期刊论文
Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications
null
期刊论文